LymphedemaV1, Main, Exploration, bibRecord, 001732

The burden of mental health in lymphatic filariasis

Identifieur interne : 001732 ( Main/Exploration ); précédent : 001731; suivant : 001733

The burden of mental health in lymphatic filariasis

Auteurs : Thanh G. N. Ton [États-Unis] ; Charles Mackenzie ; David H. Molyneux

Source :

Infectious Diseases of Poverty [ 2049-9957 ] ; 2015.

RBID : PMC:4520254

Abstract

Background

Neglected Tropical Diseases (NTDs) afflict around one billion individuals in the poorest parts of the world with many more at risk. Lymphatic filariasis is one of the most prevalent of the infections and causes significant morbidity in those who suffer the clinical conditions, particularly lymphedema and hydrocele. Depressive illness has been recognised as a prevalent disability in those with the disease because of the stigmatising nature of the condition. No estimates of the burden of depressive illness of any neglected tropical disease have been undertaken to date despite the recognition that such diseases have major consequences for mental health not only for patients but also their caregivers.

Methods

We developed a mathematical model to calculate the burden of Disability- Adjusted Life Years (DALY) attributable to depressive illness in lymphatic filariasis and that of their caregivers using standard methods for calculating DALYs. Estimates of numbers with clinical disease was based on published estimates in 2012 and the numbers with depressive illness from the available literature.

Results

We calculated that the burden of depressive illness in filariasis patients was 5.09 million disability-adjusted life years (DALYs) and 229,537 DALYs attributable to their caregivers. These figures are around twice that of 2.78 million DALYs attributed to filariasis by the Global Burden of Disease study of 2010.

Conclusions

Lymphatic filariasis and other neglected tropical diseases, notably Buruli Ulcer, cutaneous leishmaniasis, leprosy, yaws, onchocerciasis and trachoma cause significant co morbidity associated with mental illness in patients. Studies to assess the prevalence of the burden of this co-morbidity should be incorporated into any future assessment of the Global Burden of neglected tropical diseases. The prevalence of depressive illness in caregivers who support those who suffer from these conditions is required. Such assessments are critical for neglected tropical diseases which have such a huge global prevalence and thus will contribute a significant burden of co-morbidity attributable to mental illness.

Electronic supplementary material

The online version of this article (doi:10.1186/s40249-015-0068-7) contains supplementary material, which is available to authorized users.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520254

DOI: 10.1186/s40249-015-0068-7
PubMed: 26229599
PubMed Central: 4520254

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The burden of mental health in lymphatic filariasis</title>
<author><name sortKey="Ton, Thanh G N" sort="Ton, Thanh G N" uniqKey="Ton T" first="Thanh G. N." last="Ton">Thanh G. N. Ton</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1">Precision Health Economics, 555 12 th Avenue, Suite 1650, Oakland, CA 94607 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Precision Health Economics, 555 12 th Avenue, Suite 1650, Oakland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mackenzie, Charles" sort="Mackenzie, Charles" uniqKey="Mackenzie C" first="Charles" last="Mackenzie">Charles Mackenzie</name>
<affiliation><nlm:aff id="Aff2">Filariasis Programmes Support Unit, Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA UK</nlm:aff>
<wicri:noCountry code="subfield">L3 5QA UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Molyneux, David H" sort="Molyneux, David H" uniqKey="Molyneux D" first="David H." last="Molyneux">David H. Molyneux</name>
<affiliation><nlm:aff id="Aff3">LSTM NTDs, Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA UK</nlm:aff>
<wicri:noCountry code="subfield">L3 5QA UK</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26229599</idno>
<idno type="pmc">4520254</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520254</idno>
<idno type="RBID">PMC:4520254</idno>
<idno type="doi">10.1186/s40249-015-0068-7</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">000D48</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D48</idno>
<idno type="wicri:Area/Pmc/Curation">000D47</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D47</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000D98</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000D98</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">000D35</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D35</idno>
<idno type="wicri:Area/PubMed/Curation">000D35</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000D35</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000D35</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000D35</idno>
<idno type="wicri:Area/Ncbi/Merge">007694</idno>
<idno type="wicri:Area/Ncbi/Curation">007694</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">007694</idno>
<idno type="wicri:Area/Main/Merge">001734</idno>
<idno type="wicri:Area/Main/Curation">001732</idno>
<idno type="wicri:Area/Main/Exploration">001732</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The burden of mental health in lymphatic filariasis</title>
<author><name sortKey="Ton, Thanh G N" sort="Ton, Thanh G N" uniqKey="Ton T" first="Thanh G. N." last="Ton">Thanh G. N. Ton</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1">Precision Health Economics, 555 12 th Avenue, Suite 1650, Oakland, CA 94607 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Precision Health Economics, 555 12 th Avenue, Suite 1650, Oakland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mackenzie, Charles" sort="Mackenzie, Charles" uniqKey="Mackenzie C" first="Charles" last="Mackenzie">Charles Mackenzie</name>
<affiliation><nlm:aff id="Aff2">Filariasis Programmes Support Unit, Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA UK</nlm:aff>
<wicri:noCountry code="subfield">L3 5QA UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Molyneux, David H" sort="Molyneux, David H" uniqKey="Molyneux D" first="David H." last="Molyneux">David H. Molyneux</name>
<affiliation><nlm:aff id="Aff3">LSTM NTDs, Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA UK</nlm:aff>
<wicri:noCountry code="subfield">L3 5QA UK</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">Infectious Diseases of Poverty</title>
<idno type="eISSN">2049-9957</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Neglected Tropical Diseases (NTDs) afflict around one billion individuals in the poorest parts of the world with many more at risk. Lymphatic filariasis is one of the most prevalent of the infections and causes significant morbidity in those who suffer the clinical conditions, particularly lymphedema and hydrocele. Depressive illness has been recognised as a prevalent disability in those with the disease because of the stigmatising nature of the condition. No estimates of the burden of depressive illness of any neglected tropical disease have been undertaken to date despite the recognition that such diseases have major consequences for mental health not only for patients but also their caregivers.</p>
</sec>
<sec><title>Methods</title>
<p>We developed a mathematical model to calculate the burden of Disability- Adjusted Life Years (DALY) attributable to depressive illness in lymphatic filariasis and that of their caregivers using standard methods for calculating DALYs. Estimates of numbers with clinical disease was based on published estimates in 2012 and the numbers with depressive illness from the available literature.</p>
</sec>
<sec><title>Results</title>
<p>We calculated that the burden of depressive illness in filariasis patients was 5.09 million disability-adjusted life years (DALYs) and 229,537 DALYs attributable to their caregivers. These figures are around twice that of 2.78 million DALYs attributed to filariasis by the Global Burden of Disease study of 2010.</p>
</sec>
<sec><title>Conclusions</title>
<p>Lymphatic filariasis and other neglected tropical diseases, notably Buruli Ulcer, cutaneous leishmaniasis, leprosy, yaws, onchocerciasis and trachoma cause significant co morbidity associated with mental illness in patients. Studies to assess the prevalence of the burden of this co-morbidity should be incorporated into any future assessment of the Global Burden of neglected tropical diseases. The prevalence of depressive illness in caregivers who support those who suffer from these conditions is required. Such assessments are critical for neglected tropical diseases which have such a huge global prevalence and thus will contribute a significant burden of co-morbidity attributable to mental illness.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1186/s40249-015-0068-7) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Murray, Cj" uniqKey="Murray C">CJ Murray</name>
</author>
<author><name sortKey="Vos, T" uniqKey="Vos T">T Vos</name>
</author>
<author><name sortKey="Lozano, R" uniqKey="Lozano R">R Lozano</name>
</author>
<author><name sortKey="Naghavi, M" uniqKey="Naghavi M">M Naghavi</name>
</author>
<author><name sortKey="Flaxman, Ad" uniqKey="Flaxman A">AD Flaxman</name>
</author>
<author><name sortKey="Michaud, C" uniqKey="Michaud C">C Michaud</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hotez, Pj" uniqKey="Hotez P">PJ Hotez</name>
</author>
<author><name sortKey="Alvarado, M" uniqKey="Alvarado M">M Alvarado</name>
</author>
<author><name sortKey="Basanez, Mg" uniqKey="Basanez M">MG Basanez</name>
</author>
<author><name sortKey="Bolliger, I" uniqKey="Bolliger I">I Bolliger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Litt, E" uniqKey="Litt E">E Litt</name>
</author>
<author><name sortKey="Baker, Mc" uniqKey="Baker M">MC Baker</name>
</author>
<author><name sortKey="Molyneux, Dh" uniqKey="Molyneux D">DH Molyneux</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Weiss, M" uniqKey="Weiss M">M Weiss</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Perera, M" uniqKey="Perera M">M Perera</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hotez, Pj" uniqKey="Hotez P">PJ Hotez</name>
</author>
<author><name sortKey="Fenwick, A" uniqKey="Fenwick A">A Fenwick</name>
</author>
<author><name sortKey="Savioli, L" uniqKey="Savioli L">L Savioli</name>
</author>
<author><name sortKey="Molyneux, Dh" uniqKey="Molyneux D">DH Molyneux</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Braich, Ps" uniqKey="Braich P">PS Braich</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Orner, P" uniqKey="Orner P">P Orner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chang, H" uniqKey="Chang H">H Chang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thompson, Ca" uniqKey="Thompson C">CA Thompson</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Suma, Tk" uniqKey="Suma T">TK Suma</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Richard, Sa" uniqKey="Richard S">SA Richard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wijesinghe, Rs" uniqKey="Wijesinghe R">RS Wijesinghe</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Mousley, E" uniqKey="Mousley E">E Mousley</name>
</author>
<author><name sortKey="Deribe, K" uniqKey="Deribe K">K Deribe</name>
</author>
<author><name sortKey="Tamiru, A" uniqKey="Tamiru A">A Tamiru</name>
</author>
<author><name sortKey="Tomczyk, S" uniqKey="Tomczyk S">S Tomczyk</name>
</author>
<author><name sortKey="Hanlon, C" uniqKey="Hanlon C">C Hanlon</name>
</author>
<author><name sortKey="Davey, G" uniqKey="Davey G">G Davey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Salomon, Ja" uniqKey="Salomon J">JA Salomon</name>
</author>
<author><name sortKey="Vos, T" uniqKey="Vos T">T Vos</name>
</author>
<author><name sortKey="Hogan, Dr" uniqKey="Hogan D">DR Hogan</name>
</author>
<author><name sortKey="Gagnon, M" uniqKey="Gagnon M">M Gagnon</name>
</author>
<author><name sortKey="Naghavi, M" uniqKey="Naghavi M">M Naghavi</name>
</author>
<author><name sortKey="Mokdad, A" uniqKey="Mokdad A">A Mokdad</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ferrari, A" uniqKey="Ferrari A">A Ferrari</name>
</author>
<author><name sortKey="Charlson, Fj" uniqKey="Charlson F">FJ Charlson</name>
</author>
<author><name sortKey="Norman, Re" uniqKey="Norman R">RE Norman</name>
</author>
<author><name sortKey="Patten, Sb" uniqKey="Patten S">SB Patten</name>
</author>
<author><name sortKey="Freedman, G" uniqKey="Freedman G">G Freedman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ramaiah, K" uniqKey="Ramaiah K">K Ramaiah</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Whiteford, Ha" uniqKey="Whiteford H">HA Whiteford</name>
</author>
<author><name sortKey="Degenhardt, L" uniqKey="Degenhardt L">L Degenhardt</name>
</author>
<author><name sortKey="Rehm, J" uniqKey="Rehm J">J Rehm</name>
</author>
<author><name sortKey="Baxter, Aj" uniqKey="Baxter A">AJ Baxter</name>
</author>
<author><name sortKey="Ferrari, Aj" uniqKey="Ferrari A">AJ Ferrari</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eaton, Ww" uniqKey="Eaton W">WW Eaton</name>
</author>
<author><name sortKey="Martins, Ss" uniqKey="Martins S">SS Martins</name>
</author>
<author><name sortKey="Nestadt, G" uniqKey="Nestadt G">G Nestadt</name>
</author>
<author><name sortKey="Bienvenu, Oj" uniqKey="Bienvenu O">OJ Bienvenu</name>
</author>
<author><name sortKey="Clarke, D" uniqKey="Clarke D">D Clarke</name>
</author>
<author><name sortKey="Alexandre, P" uniqKey="Alexandre P">P Alexandre</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Californie</li>
</region>
</list>
<tree><noCountry><name sortKey="Mackenzie, Charles" sort="Mackenzie, Charles" uniqKey="Mackenzie C" first="Charles" last="Mackenzie">Charles Mackenzie</name>
<name sortKey="Molyneux, David H" sort="Molyneux, David H" uniqKey="Molyneux D" first="David H." last="Molyneux">David H. Molyneux</name>
</noCountry>
<country name="États-Unis"><region name="Californie"><name sortKey="Ton, Thanh G N" sort="Ton, Thanh G N" uniqKey="Ton T" first="Thanh G. N." last="Ton">Thanh G. N. Ton</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001732 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001732 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4520254
   |texte=   The burden of mental health in lymphatic filariasis
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:26229599" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

Serveur d'exploration sur le lymphœdème

The burden of mental health in lymphatic filariasis

The burden of mental health in lymphatic filariasis

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.